Current Opinion in Infectious Diseases, February 2017 – Volume 30 – Issue 1 – p 77–86
This review provides an update on the need, development status, and important next steps for advancing development of vaccines against sexually transmitted infections (STIs), including herpes simplex virus (HSV), Neisseria gonorrhoeae (gonorrhea), Chlamydia trachomatis (chlamydia), and Treponema pallidum (syphilis).
Major progress is being made in addressing the large global unmet need for STI vaccines. With continued collaboration and support, these critically important vaccines for global sexual and reproductive health can become a reality.
A group of researchers have cleared up an important question about HIV transmission, in experiments on mice. Although HIV-infected CD4 cells persist in the vagina even on antiretroviral therapy (ART) that fully suppresses free HIV in the blood and body fluids, these cells are not anything like numerous enough to pose any transmission threat.