Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease

Li D, Jin M, Bao P, Zhao W, Zhang S. Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019. JAMA Network Open. 2020;3(5):e208292. doi:10.1001/jamanetworkopen.2020.8292

Research Letter

Infectious Diseases

May 7, 2020


In this cohort study, we found that SARS-CoV-2 can be present in the semen of patients with COVID-19, and SARS-CoV-2 may still be detected in the semen of recovering patients. Owing to the imperfect blood-testes/deferens/epididymis barriers, SARS-CoV-2 might be seeded to the male reproductive tract, especially in the presence of systemic local inflammation. Even if the virus cannot replicate in the male reproductive system, it may persist, possibly resulting from the privileged immunity of testes. So far, researchers have found 27 viruses associated with viremia in human semen. But the presence of viruses in semen may be more common than currently understood, and traditional non–sexually transmitted viruses should not be assumed to be totally absent in genital secretions.5,6 Studies on viral detection and semen persistence are beneficial to clinical practice and public health, especially concerning viruses that could cause high mortality or morbidity, such as SARS-CoV-2.

This study is limited by the small sample size and the short subsequent follow-up. Therefore, further studies are required with respect to the detailed information about virus shedding, survival time, and concentration in semen.

If it could be proved that SARS-CoV-2 can be transmitted sexually in future studies, sexual transmission might be a critical part of the prevention of transmission, especially considering the fact that SARS-CoV-2 was detected in the semen of recovering patients.

Future prospects for new vaccines against STIs

Current Opinion in Infectious Diseases, February 2017 – Volume 30 – Issue 1 – p 77–86
This review provides an update on the need, development status, and important next steps for advancing development of vaccines against sexually transmitted infections (STIs), including herpes simplex virus (HSV), Neisseria gonorrhoeae (gonorrhea), Chlamydia trachomatis (chlamydia), and Treponema pallidum (syphilis).

Major progress is being made in addressing the large global unmet need for STI vaccines. With continued collaboration and support, these critically important vaccines for global sexual and reproductive health can become a reality.

  • Full text (open access) available here

HIV-infected vaginal cells do not transmit HIV if plasma viral load is undetectable

nam/aidsmap, 15 February 2016

A group of researchers have cleared up an important question about HIV transmission, in experiments on mice. Although HIV-infected CD4 cells persist in the vagina even on antiretroviral therapy (ART) that fully suppresses free HIV in the blood and body fluids, these cells are not anything like numerous enough to pose any transmission threat.

Read more here