Transgender women taking PrEP have lower levels of PrEP drugs than cisgender men

aidsmap/nam, November 9th 2018

A study presented at October’s HIV Research for Prevention conference (HIVR4P) in Madrid shows that transgender women who are taking feminising hormones and also taking pre-exposure prophylaxis (PrEP) have levels of the PrEP drugs tenofovir and emtricitabine in their blood that are about 25% lower than those in cisgender men, and levels in rectal tissue cells about 40% lower. Tenofovir levels in rectal tissue were 44% lower.

However, the study also confirmed that the interaction between hormones and PrEP did not appear to go the other way; blood levels of estradiol, the one hormone all of the transgender women took in one form or another, do not appear to be affected by PrEP.

 

Sperm counts among western men have halved in last 40 years – study

The Guardian, Wednesday 26 July 2017 

Sperm counts among men have more than halved in the last 40 years, research suggests, although the drivers behind the decline remain unclear.

The latest findings reveal that between 1973 and 2011, the concentration of sperm in the ejaculate of men in western countries has fallen by an average of 1.4% a year, leading to an overall drop of just over 52%.

Little has been done to address the root of the issue, and sperm counts might also be an indicator of poorer health among men more generally.